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The study determined that tarlatamab was tolerable and did not reveal any new safety signals. The results of a study evaluating tarlatamab in neuroendocrine prostate cancer were presented at asco 2024. Current systemic therapies for advanced disease, including targeted therapies, chemotherapy, and immunotherapy, are associated with limited duration of response
Naobi Asanti
New therapeutic targets are needed. Should we be using tarlatamab for neuroendocrine prostate cancer Tarlatamab is approved for treatment of patients with extensive stage small cell lung cancer, and may be effective at treating patients with neuroendocrine neoplasms or other solid tumors that express the dll3 protein.
Yes, ongoing research is evaluating tarlatamab in combination with immune checkpoint inhibitors (such as durvalumab or atezolizumab) and chemotherapy to improve outcomes in patients with neuroendocrine tumors.
Nepc is an aggressive form of prostate cancer with poor prognosis and no standard treatment approach.
